The genetic aortic aneurysm syndromes Marfan, Loeys–Dietz, and aneurysms-osteoarthritis (AOS), involving the FBN1, TGFBR1, TGFBR2, TGFB2, and SMAD3 genes were first identified in patients with pathologic dilatation or aneurysm of the thoracic aorta with multisystem overlapping cardiovascular, skeletal and ocular manifestations (Boileau et al. 2012; Cook et al. 2014; Dietz et al. 1991; Loeys et al. 2006; van de Laar et al. 2011). Here, SMAD3 is linked to aneurysm.