In response to oxidative stress, activated Nrf2 recognizes and binds to ARE of cytoprotective and detoxification genes, including NAD(P)H:quinone oxidoreductase (NQO1), and then Nrf2 stimulates transcriptional activation of genes in CML cells. Here, NQO1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.