We selected those genes with functions known to be associated with cancer of which there were 12—SNVs: NOTCH2, PIK3CG, IL2RB, BAI3, FREM2 and RERE; indels: UTRN, CDHR3, NCOA5, CABYR, HOTAIR and FOLH1 (Table 2). The gene discussed is FREM2; the disease is cancer.