APOE and cardiovascular disorder: A possible mechanism of the development of cardiovascular disease by strong sudden cooling weather during the heat wave process may be summarized as follows: a heat wave can increase the myocardial HSP60 content of ApoE−/− mice [19], and the excess HSP60 can activate immune cells and induce endothelial cells and macrophages to secrete numerous inflammatory cytokines, such as ICAM-1 and TNF-α [20,21].