The tissue specificity of IAI.3B promoter and AdE3-IAI.3B for ovarian cancer was reported previously,22 but specificity for cervical cancer, skin cancer, esophageal cancer, head and neck cancer, glioma, lung cancer, stomach cancer, colon cancer, pancreatic cancer, liver cancer, prostate cancer, breast cancer, mesothelioma, and neurofibromatosis type 1 (NF1) cells has not yet been reported. Here, NF1 is linked to colonic neoplasm.