Although solenopsin A recruits PTEN to lipid rafts (Additional file 1: Figure S3), it does not appear to be enough to dephosphorylate Akt (Additional file 1: Figure S4) in the human melanoma cell lines A375 and A2058 (both are wild type p53) like it did in 786-O renal cell carcinoma cells (mutant p53) [1]. The gene discussed is TP53; the disease is hereditary clear cell renal cell carcinoma.