Unexpectedly, we found that solenopsin A increases Akt phosphorylation in cells with wild type p53 (A375 and A2058), while it decreases Akt activation in cells with defective p53 function (SVR and 786-O) (Additional file 1: Figure S4), thus demonstrating a context dependent effect on tumor cells [1,38]. Here, AKT1 is linked to neoplasm.