Since Snail and serpinA1 are expressed not only in CRC but also in other types of cancer, [3, 16-18] we also examined the role of Snail and serpinA1 in breast and ovarian cancer cells (MCF7, MDA-MB-231, A2780, and SKVO3 cells) by modulating their expression. The gene discussed is SERPINA1; the disease is colorectal carcinoma.