TACSTD2 and cancer: In this study, we demonstrate for the first time that Trop-2, an anti-adhesive and pro-migratory transmembrane protein, is up-regulated in human PCa with extracapsular extension (stages pT3/pT4) as compared to organ-confined (stage pT2) PCa, suggesting that this molecule plays a crucial role during cancer progression toward a metastatic phenotype.