Although more work is needed to fully elucidate the pro-invasive signaling pathways mediated by Trop-2 in PCa cells, the data presented here suggest that modulation of the Trop-2/α5β1 complex may provide new insights in the functional stratification of PCa patients with higher metastatic propensity and, therefore, in need of more aggressive treatments. The gene discussed is TACSTD2; the disease is posterior cortical atrophy.