In NSCLC cells expressing the above mentioned activating mutations (PC9 and HCC-827 cells), CNX-2006 concentrations ranging between 55 and 104 nM were sufficient to reduce to 50% (IC50) the phosphorylation of EGFR after 2 hours treatment (Figure 1B). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.