MARCKS and neoplasm: Previous studies have established the role of phospho-MARCKS in directing cell movement of vascular endothelial cells [46]; our results herein coupled with their findings not only confirm that up-regulation of phospho-MARCKS plays a critical role in tumor-related angiogenesis, but also suggest that phospho-MARCKS is a previously unrecognized, useful target for combination therapy regimes that seek to synergistically enhance paclitaxel efficacy by targeting angiogenesis.