These acetylated proteins or the ‘acetylome’ include transcription factors p53 [5, 6], STAT3 [7, 8], and the NFκB family member p65 [9-11], a target that may be of particular relevance in myeloma cells which are recognised as being highly dependent on NFκB signalling [12]. Here, NFKB1 is linked to plasma cell myeloma.