Of note, recent studies have revealed that IL-27 exerts potent antitumor effects against various tumor models via different mechanisms, including CD8+T cells, natural killer (NK) cells, antibody-dependent cell-mediated cytotoxicity (ADCC), antiangiogenesis, direct suppression of tumor growth, and inhibition of cychroxygenase-2 (COX-2) expression, depending on the characteristic of each tumor [21–25]. Here, CD8A is linked to neoplasm.