Although no association between IL-27 polymorphisms and immune thrombocytopenia, esophageal cancer, glioma, type 1 diabetes, or nasopharyngeal was observed in previous reports, our recent study suggested that IL-27 gene polymorphisms may play important roles in the susceptibility to epithelial ovarian cancer [30, 31, 39–42]. This evidence concerns the gene IL27 and esophageal cancer.