The univariate Kaplan-Meier analysis showed that low mRNA expression of TMPRSS1 (log rank, P = 0.042; Fig. 2a) and TMPRSS3 (log rank, P = 0.015; Fig. 2b) predicted poorer breast cancer-specific survival compared to high expression, as did low expression of the TMPRSS3 protein (log rank, P = 0.028; Fig. 2d) during the 20-year follow-up period. Here, HPN is linked to breast cancer.