TMPRSS3 and breast cancer: When the treatment data was included in the survival analyses, low TMPRSS3 mRNA expression was associated with poor breast cancer-specific survival (log rank, P = 0.039) in all the treated patients and remained an independent factor predicting more frequent relapse occurrence (log rank, P = 0.023; Cox regression analysis, P = 0.021; HR, 1.831; 95 % CI, 1.094–3.063).