EGFR and non-small cell lung carcinoma: Several studies have reported that TKI treatment results in high response rates (70–89 %) and increased overall survival (OS) and progression-free survival (PFS) (12.9–19.8 months and 6.6–23.3 months, respectively) in selected populations of EGFR-mutated NSCLC patients with BM [7–9].