Usual interstitial pneumonia (UIP) is the histopathology underlying IPF and is characterized by heterogeneity of disease and accumulation of fibroblast foci and collagen with an emphasis on collagen type I (col1) over type III (col3) [1, 2], and abnormalities in other matrix molecules including elastin [3]. The gene discussed is ELN; the disease is idiopathic interstitial pneumonia.