SERPINA5 (Protein C inhibitor), a member of the serine protease inhibitor superfamily know to have anti-metastatic and anti-angiogenic effects, [62] is down-regulated in human HCC tissues and further assessment of it’s anti-tumourigenic activity demonstrated that this was mediated by effects on the fibronectin-integrin β1 signalling pathway [63]. Here, SERPINA5 is linked to hepatocellular carcinoma.