In PCa cells, 4E-BP1 protein was higher in androgen-independent and osseous metastatic C4-2 and C4-2B cells compared to LNCaP cells (Fig. 3A), similar to PC-1 expression data in an LNCaP/C4-2 PCa progression model [15]. Here, EIF4EBP1 is linked to posterior cortical atrophy.