In this regard, EGR1 has been shown to induce Cav3.2 T-type calcium channels, which plays a role in inducing calcineurin/NFAT signaling during cardiac hypertrophy [27], to play an important role in adaptive response to hypertrophic stimuli [28], and to be targeted and suppressed by Atf3during endothelin-1 induced cardiomyocyte hypertrophy [29]. Here, EDN1 is linked to cardiac hypertrophy.