The higher BAL fluid IL-8 levels in uncontrolled asthma seen in our study could reflect persistent stimulation of IL-8 secretion by chronic stimulation of the nuclear factor-κB signaling pathway following exposure to environemantal factor [19], or intrinsic differences in the ability of uncontrolled asthma patients’ airway epithelium to produce high amounts of IL-8 [20]. Here, CXCL8 is linked to asthma.