Two of these genes are VIPs: SCN9A, which codes for Nav1.7 sodium channel and whose allelic variants are implicated in genetic epilepsies with febrile seizures [46, 47] and RTN2, also a VIP in L-DE network module C, a regulator of the trafficking and function of glutamate transporter EAAC1 (excitatory amino acid carrier 1) [48]; dysregulation of EAAC1 was reported in experimental models of epilepsy and also in the hippocampus of temporal lobe epilepsy (TLE) patients [49]. The gene discussed is RTN2; the disease is epilepsy.