SYN2 and epilepsy: Noteworthy, community A harbors SYN2, a VIP that encodes Synapsin II, a phosphoprotein which desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic Ca channels, modulating synaptic transmission and plasticity; allelic variants of SYN2 contribute to epilepsy predisposition [65, 66].