Accordingly, the C-F “axis’ also harbors genetic and molecular hallmarks of epilepsy, such as: i) in community C the L-type calcium channel gene CACNA1, RTN2, a regulator of EAAC1 (also a VIP in E-DE network), the calcium binding/signaling genes TESC, CALM3, EFHD2; ii) in community F the gene CTNAP1, regulator of the glutamate receptor subunit GluA1. The gene discussed is TESC; the disease is epilepsy.