This C-I “axis”, described earlier in this paper, harbors high hierarchy genes with relevant roles in febrile-driven epilepsy and MTLE, such as SCN9A, RTN2 and BAIAP2, in community C, and B3GALTN1, KCN3 and MTA1 in community I. This synaptic excitability “axis” is seconded by the axis A-B, whose high hierarchy genes are also related to pro-epileptic roles, as SYN2 and NIDD (ZDHHC23). The gene discussed is ZDHHC23; the disease is epilepsy.