The other significant connections of community C (Fig 6B) occur with community A—where are located SNX25 and ARPC5L, markers of intractable epilepsy—and with communities H and B which harbor, respectively, the genes MTA1 (a high-hub in E-DE community I, functionally described above) and RBPL1, regulators of two epilepsy-associated genes (HDAC2 and PAX6, targets of the antiepileptic drug Valproate). The gene discussed is HDAC2; the disease is epilepsy.