HBEGF is a potent mitogen for keratinocytes, hepatocytes, smooth muscle cells and fibroblasts, and its expression is elevated in human cancers, including hepatocellular and gastric carcinoma, breast carcinoma, melanoma, colon cancer, pancreatic cancer, glioma and glioblastoma [35]. The gene discussed is HBEGF; the disease is malignant colon neoplasm.