In conclusion, this study is the largest cohort of patients that demonstrated a strong association between HLA-DRB1 and DQB1 alleles, especially HLA-DRB1*15:01, DRB1*16:02, DQB1*05:01 and DQB1*05:02, and disseminated opportunistic infection with acquired anti-IFN-γ autoantibody. This evidence concerns the gene IFNG and Opportunistic infection.