SERPINE1 and Insulin resistance: Furthermore, the level of leptin (an adipocytokine) was positively correlated with insulin resistance (fasting glucose level, fasting insulin level and HOMA-IR), lipid profiles (LDL-c, TG and TC levels), and inflammatory markers (hs-CRP, MCP-1, TNF-α, and PAI-1 levels) but negatively correlated with the adiponectin level.