We hypothesised that EPO would increase peripheral BDNF levels since EPO infusion, as previously mentioned, increases CNS BDNF in preclinical models, and in several human studies of patients with neurodegenerative and neuropsychiatric conditions EPO is also associated with neuroprotective and neuroproliferative potentials [16], including TRD and BD [21;22]. The gene discussed is BDNF; the disease is Behcet disease.