Though similar growth suppression effect is observed in variety of cancers, including HCC, the associated effects are correlative; it has been shown to induce both caspase dependent and caspase independent apoptosis, inhibit cell invasion, angiogenesis, nuclear factor activation, and Notch1 reduction [25, 28–30, 36, 37]. The gene discussed is NOTCH1; the disease is hepatocellular carcinoma.