CASP3 and neoplasm: In contrast, the number of tumor cells that were positive for cleaved caspase-3 was significantly increased in GA-treated KrasLA2 lung tumors (cells/hpf: 59.8 ± 2.9 vs. 12.5 ± 5.2 of control, P < 0.01, n = 4) (Fig 7C).