The first human protein produced in the moss system was the vascular endothelial growth factor (VEGF) (Baur et al., 2005a; Gorr et al., 2001; Koprivova et al., 2004), which has a central function in angiogenesis and in cancer (Goel and Mercurio, 2013; Roskoski, 2007). The gene discussed is VEGFA; the disease is cancer.