Overload effects on the degradation pathway due to a potential change in glomerular permeability can be eliminated as i) even in overload proteinuria (when plasma albumin is artificially increased by intravenous injection of exogenous intact albumin), peptide excretion is readily observed [53] and ii) there is little or no change in glomerular permeability in PAN [6,20,54] in spite of glomerular structural changes [35]. Here, ALB is linked to polyarteritis nodosa.