Nonetheless we could demonstrate that WWOX silencing blunted sensitization to TRAIL-induced cell death in S66A expressing SW480 cells and that loss of WWOX expression in the liver and pancreatic cancer cell lines prevented TRAIL signalling regulation by ectopic stable expression of ezrin, irrespective of its phosphorylation status on serine 66. The gene discussed is WWOX; the disease is familial pancreatic carcinoma.