Like WT ezrin, the actin-binding deficient mutant R579A inhibited apoptosis induced by FasL and TRAIL (Fig 2F and S4 Fig), suggesting that inhibition of apoptosis induced by death receptor ezrin in colon cancer cells can occur independently of the cytoskeleton-binding properties of ezrin. The gene discussed is TNFSF10; the disease is malignant colon neoplasm.