Interestingly, whereas both colon carcinoma cell lines SW480 and HCT116 express WWOX, two pancreatic cell lines, MIA PaCa-2 and PANC-1 as well as the SK-HEP-1 liver cancer cell line (Fig 5A) do not, and ectopic expression of ezrin wt in MIA PaCa-2 or SK-HEP-1 failed to regulate apoptosis induced by FasL or TRAIL (Fig 5B). This evidence concerns the gene EZR and colon carcinoma.