Since COX-2 and iNOS transcription are regulated by NFκB and STAT3 [6,37–39] and since both COX-2 and iNOS contribute to neuroinflammatory processes in AD [5], we also investigated whether Cox-2 and iNOS mRNA expression were affected by anatabine in the brains of Tg PS1/APPswe mice. This evidence concerns the gene PTGS2 and Alzheimer disease.