Shin et al. [27] analyzed the regulator role of Nrf-2 in liver protection by diverse agents (hepatitis B and C viruses, the damage caused by APAP or ethanol), or in diseases such as hepatic alcoholic steatosis, non-alcoholic steatosis, fibrosis, cirrhosis, and hepatocarcinoma. The gene discussed is NFE2L2; the disease is Cirrhosis.