Previous studies reported a hyperglycemia induced activation of rat PSCs, but only up to 72 hours and without a genome-wide approach.[24–26] We found that human PSCs increased the cytoplasmic αSMA micro-filament formation and tended to increase major ECM protein constituents (type-1 and -3 collagens) upon exposure to CHG. Here, ACTA1 is linked to Hyperglycemia.