This includes the induction of increased CXCL12 production by human pancreatic stellate cells and upregulation of CXCR4 expression on human cancer cells that in combination with the finding that hyperglycemia also directly enhanced cancer cell migration, suggests that it may promote both the tumor growth and the spread of pancreatic cancer. The gene discussed is CXCL12; the disease is familial pancreatic carcinoma.