A variety of PSC activating factors (e.g.: EtOH, TGF-β1, PDGF, TNFα, interleukines [IL-1,-6,-13], ROS) were previously identified, but the role of chronic (i.e.>14 days) hyperglycemia in PSC activation has not been investigated to date. The gene discussed is TGFB1; the disease is Hyperglycemia.