The hsa-mir-509-3p is constitutively expressed in the 37 tumor tissues from untreated CRC patients with different genotypes; however, there was no significant association between the background expression of hsa-mir-509-3p and the CD44 rs13347C/T genotypes (0.037±0.008 for CC; 0.027±0.005 for CT and 0.029±0.011 for TT; ANOVA test: P = 0.579) (Fig 1E). Here, CD44 is linked to neoplasm.