While upregulation CaV1.3 has been observed in prostate cancer and its pharmacological blockade inhibits growth in prostate cancer cell lines, the CaV1 blocker, nifedipine, however, has been implicated in the proliferation of certain cancers and its effects are likely not mediated by blocking CaV channels [88,91]. The gene discussed is CACNA1D; the disease is prostate cancer.