Intriguingly, IκB-ζ was not expressed in other NF-κB dependent hematologic malignancies such as Hodgkin’s lymphoma or multiple myeloma, indicating that IκB-ζ plays a selective role in mediating and controlling NF-κB activity in ABC DLBCL [49]. The gene discussed is NFKBIZ; the disease is diffuse large B-cell lymphoma.