Recent in vitro and in vivo studies have demonstrated a potential neuroprotective role of NRF2, attenuating neurotoxicity in 6-hydroxydopamine, hydrogen peroxide, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced models of PD [7–9]. Here, NFE2L2 is linked to Parkinson disease.