NFKB1 and cervical carcinoma: In addition, the studies found that the expression of miR-21 was significantly up-regulated in the transition from normal to cervicitis corresponding with down-regulation of PDCD4. This may represent an important event in the role of miR-21 in carcinogenesis and an inflammatory response such as: First, by down-regulation of molecule PDCD4 [40] resulting in suppression of the inflammation process via transcriptional factor NF-kB and activated anti-inflammatory cytokine, interleukin 10 (IL-10) [41, 42] leading to immune evasion and cervical cancer progression.