Given the increasing incidence and mortality of HCC with the high HBV-infection background in China, we systematically analyzed the metabolic function, protein and gene expression levels of UGT1A, UGT1A1, UGT1A9, UGT1A4 and UGT2B7 in HBV-positive HCC tumor and the adjacent normal tissues. Here, UGT1A4 is linked to hepatocellular carcinoma.