UGT2B7 and hepatocellular carcinoma: In summary, given the important roles of UGTs played in biotransformation and detoxification, the consistently decreased metabolic activities and protein expression level of UGT1As and UGT2B7 in our study will provide relevant information for the clinical regimen, forecasting the toxicity and efficacy of drugs in HBV-positive HCC patients, and for improving therapeutic outcome of first line anti-cancer agents such as tamoxifen and SN-38.