In addition, the simultaneous re-expression of FSCN1 compromised the miR-145-supressed cell migration and invasion ability almost completely in miR-145-transfected MGC-803 and SGC-7901 cells, which indicated that the repression of FSCN1 is necessary for miR-145 to inhibit the migration and invasion of gastric cancer cells. Here, FSCN1 is linked to gastric cancer.