More extended follow-up is critical, particularly for women with hormone receptor-positive disease who have a risk of disease recurrence that extends for many years.” On the other hand, Partridge acknowledged, “decisions in the clinic cannot always wait until more solid data are available.” Given that Dr. Azim’s data using GnRH antagonist-based COS is the only data available regarding safety of COS in women with cancer, it is surprising to note that only 12% of the respondents in this study reported that they preferred GnRH antagonist-based COS for women with cancer. The gene discussed is NR4A1; the disease is cancer.