IGFBP5 and melanoma: To test whether IGFBP5 suppressed melanoma growth and metastasis through inhibition of this signaling pathway, we examined the phosphorylation of ERK and p38-MAPK and found that their phosphorylation levels decreased in A375 IGFBP5 OE cells and increased in A2058 IGFBP5 KD cells (Figures 6, panels A and B, and Figures S4, panels A and B).