Hence, in order to define the role of IGFBP5 in MM growth and metastasis, we investigated the effects of IGFBP5 in A375 and A2058 human melanoma cells and its potential as a potent tumor growth inhibitor and anti-metastatic agent both in vitro and in vivo, using stable overexpression and knockdown cells. Here, IGFBP5 is linked to melanoma.