Others also demonstrated in C6 glioma cells that n-3 PUFAs are ligands for receptors that activate PGC-1α (Desvergne & Wahli, 1999), leading to increased expression of PGC-1α, transcription factor-A mitochondrial (TFAM), cytochrome c oxidase, and increased the mitochondrial membrane potential (Jeng et al., 2009). The gene discussed is PPARGC1A; the disease is central nervous system cancer.