CLOCK and cancer: For example, CLOCK mutant mice develop a broad syndrome of metabolic dysregulation and neurological disturbance 52, 53; Bmal1 knockout mice are infertile, have diminished organ and body size and display an advance in age‐related characteristics and increased oxidative stress in the kidney, heart, and spleen 54, 55; Per2 deficient mice show increased bone mass, and are prone to cancer 56, 57, 58; and Reverbα knockout mice are obese, exhibit altered lipid metabolism, and aberrant thermogenesis 59, 60, 61.