Univariate Cox regression model analysis revealed that poor survival was significantly associated with tumor size (hazard ratio, HR: 1.99, 95% confidence interval, 95%CI: 1.01-3.92; P = 0.047), differentiation (HR: 3.09, 95%CI: 1.43-6.65; P = 0.004), colonic wall invasion (HR: 2.46, 95%CI: 1.25-4.83; P < 0.009), nodal metastasis (HR: 3.20, 95%CI: 1.62-6.31; P = 0.001), AJCC (American Joint Commitee on Cancer) stage (HR: 3.87, 95%CI: 1.93-7.76; P < 0.001), S100P expression (HR: 2.72, 95%CI: 1.13-6.58; P = 0.026), and SOX9 expression (HR: 2.34, 95%CI: 1.02-5.38; P = 0.045). The gene discussed is S100P; the disease is cancer.