Overexpression of HMGA proteins, a general feature of human malignancies [3], has a critical role in cancer progression since it inhibits p53-dependent apoptosis by modulating transcription of p53 [27] and p53-target genes (reviewed in [14]), impairs DNA repair [28] and induces the epithelial-mesenchymal transition (EMT) [29, 8]. This evidence concerns the gene TP53 and cancer.