CEMIP and breast carcinoma: The H3K4me3 modification was highly enriched in MDA-MB-231 cells, an aggressive human breast cancer cell line that expresses high levels of CEMIP, as compared to MCF-7 cells, which express lower levels of CEMIP (Fig. 5B) [1], demonstrating a correlation between CEMIP expression and the level of the H3K4me3 mark.