As shown for one CRC patient in Figure 4A-4C and for seven CRC patients in Figure 4D-4F, Tim-3+CD8+ T cells produced significantly less IFN-γ than Tim-3−CD8+ T cells when TILs in tumors were examined (p = 0.0032, Figure 4D) and lymphocytes in noncancerous tissues were examined (p = 0.0369, Figure 4E). The gene discussed is HAVCR2; the disease is colorectal carcinoma.