The significant difference was observed between patients with advanced tumor and healthy donors while patients with stage I/II had a moderately increased percentage of circulating Tim-3+PD-1+CD8+ T cells, although we did not observe significant correlation between the Tim-3+PD-1+CD8+ T cells and histologic grade and serum concentrations of cancer biomarker CEA and CA199. This evidence concerns the gene HAVCR2 and cancer.