RAB7A and melanoma: Here we used a combination of functional studies in normal- and oncogene-transduced melanocytes, as well as human melanoma cell lines, clinical biopsies and mouse models with a triple objective: (i) define the identity of membrane-trafficking deregulators acting upstream of RAB7, (ii) determine the stage during melanoma genesis when this dependency is established, and (iii) dissect the signalling cascades involved.