RAB7A and melanoma: Interestingly, from the different sources of endomembranes in mammalian cells (i.e. the plasma membrane, the ER, the Golgi or the autophagy machinery) [10, 45, 46], electron microscopy and real-time analyses of membrane trafficking revealed macropinocytosis as the main responsible of the aberrant endosomal surplus induced in melanoma cells upon RAB7 suppression.