In this context, the need for high RAB7 levels to counteract the enhanced PI3K-driven macropinocytic influx of oncogene-expressing melanocytic cells provides a plausible explanation for the selection of cooperating events (e.g. SOX10 and MYC induction) that increase the overexpression of this GTPase already at the stage of melanoma initiation [13]. The gene discussed is PIK3CD; the disease is melanoma.