Events activating PI3K in mutated NRAS and BRAF-driven melanomas (i.e. PTEN loss) [42], further expand the requirement of RAB7 and the roles of macropinocytosis (e.g. scavenging nutrients such as albumin and amino acids, lipids and extracellular ATP [3, 4]) to a broader spectrum of melanocytic lesions. The gene discussed is PTEN; the disease is melanoma.