CNR1 and cancer: Indeed, according to the role of STAT3 in the promotion of survival and proliferation, but also in the immune escape of cancer cells, SR141716, besides a direct antiproliferative potential, specifically induces expression of NKG2D ligand MICA/B in malignant but not in healthy neuronal cells, leading to a specific stimulation of NK-antitumor immune response at a degree that seems to be correlated to the levels of CB1 immunoreactivity.