CNR1 and neoplasm: Up to now our data highlighted, indeed, that a strict directional correlation between CB1 and STAT3 was found both in almost all tumor tissues (18/23) and in all patients primary cell lines where the levels of phosphorilated-STAT3 followed the trend of the CB1 expression (Figs. 3D and 6B, Figs. 4E and 6C), suggesting that Tyr705 phosphorylation of STAT3 in these cells may be dependent on the signaling through this G-protein coupled receptor (GPCR), in line with CB1 receptor knockdown experiments too (Fig. 6F).