At the light of these findings the inhibition of STAT3 activation might really account not only for removal of STAT3-mediated repression of MICA [33], but also for drug effects on glioma growth and apoptosis, even though we cannot rule out an antiproliferative effect of SR141716 probably via TGF-β signaling blockage. The gene discussed is STAT3; the disease is central nervous system cancer.