The recent evidence that deletion of mouse astroglial CB1 receptors impairs leptin-mediated STAT3 activation [35], along with that electroacupuncture (EA) pretreatment enhances active form of STAT3 via CB1 receptor to protect against cerebral ischemia [36], support our findings corroborating the CB1-STAT3 axis as a new potential oncogenic network in brain that deserves much attention in the near future. Here, STAT3 is linked to brain ischemia.