In the present study, we found that (i) CD93 was increased and expressed in endothelial cells in blood vessels in CRC tissue; (ii) the plasma level of CD93 was lower in the CRC patients compared with the controls; (iii) the T/T genotype of rs2749817, a CD93-related SNP, was associated with disseminated cancer and an increased recurrence rate in patients that had the entire tumour removed at operation, which correlated to higher CD93 levels in the cancer. Here, CD93 is linked to neoplasm.